Description
Product Characteristics:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Subcellular location: Nucleus
Synonyms: FKSG45, Protease FKSG45, SENP5, SENP5_HUMAN, Sentrin specic protease SENP5, Sentrin-specic protease 5, Sentrin/SUMO specic protease SENP5, Sentrin/SUMO-specic protease SENP5, SUMO specic protease SENP5, FLJ42398, MGC27076.
Target Information: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1\, MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]